![]() ![]() ![]() All subjects provided a written informed consent prior to enrollment into the study. Here, we report results from a monocentric, randomized, controlled study evaluating the efficacy of a hydrolyzed collagen supplement (Lapi Gelatine, Empoli, Italy) for the improvement of hydration, elasticity, and the appearance of wrinkles.Ī randomized controlled study to evaluate the efficacy of a hydrolyzed collagen supplement was conducted in 2020 at Dermo-Cosmetic and Medical R&D Center of Bio Basic Europe in Milan, Italy. Many studies have already been performed to evaluate the effect of hydrolyzed collagen in improving the appearance and properties of the skin, 9, 10 but more clinical studies are needed to better investigate the benefits of hydrolyzed collagen on the skin. Minor side effects, such as nausea, flatulence, or dyspepsia can occur in some people ingesting collagen peptides. Furthermore, based on the results of international research, 6, 8 both the World Health Organization (WHO) and the European Commission for Health and Consumer Protection have stated that hydrolyzed collagen is safe. The United States Food and Drug Administration (FDA) has classified gelatin, from which collagen peptides are prepared, as a safe substance. 7 In the dermis, hydrolyzed collagen exerts a dual mechanism of action: 1) free amino acids contribute to the formation of collagen and elastin fibers and 2) collagen oligopetides stimulate the production of new collagen, elastin and hyaluronic acid. Once administered orally, the collagen peptides and free amino acids are then distributed into the dermis, where they can remain for up to 14 days. 6 The quality of the final hydrolyzed collagen depends on its average molecular size, which can vary according to the method used to extract it. Due to its low molecular weight, hydrolyzed collagen is easily digested, absorbed, and distributed in the human body. 3 – 5 Hydrolyzed collagen consists of small peptides with a low molecular weight (0.3–8 kDa). Collagen peptides are the product of the enzymolysis of collagen or gelatin and are used as important active components due to their various bioactivity, high bioavailability, and good biocompatibility. Recently, researchers have devoted some attention to protein hydrolyzates as dietary supplements with the potential to improve signs of skin aging. These factors contribute to the appearance of skin aging, with a reduction in its elasticity and tone, giving way to the increased appearance of wrinkles, sagging eyelids, and bags under the eyes. In addition, with advancing age there is also a loss of hyaluronic acid. With age, collagen fibers become thicker and shorter consequently, Type I collagen is lost. ![]() Collagen synthesis changes as we age: younger skin comprises 80-percent Type I collagen and about 15-percent Type III collagen. ![]()
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